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Background-Steroid-induced gene regulation in the endocrine tissues and vascular wall is achieved through the interaction of specific receptor proteins and promoters of target genes. In addition to these delayed steroid actions, rapid effects of steroids have been reported in various tissues that were clearly incompatible with the classic theory of genomic steroid action. Methods and Results-Because high doses of 17␤-estradiol have been shown to modulate intracellular cAMP levels in vasculardoi:10.1161/01.cir.99.11.1485 pmid:10086974 fatcat:ch75kkghlbavvazd2b63m3mihq