The present study was conducted to evaluate the impact of probiotic, prebiotic and synbiotic on haematological parameters of cross bred calves. Twenty four crossbred calves with average age of fifteen days were divided into 4 groups of 6 calves each. The calves were assigned to different dietary treatments viz. T 0-basal diet (control), T 1 (probiotic group) -basal diet + Lactobacillus acidophilus @ 1 g/calf/day (2 x 10 10 cfu/ g), T 2 (prebiotic group) -basal diet + Mannan oligosaccharide

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... @ 4 g per calf/day and T 3 (synbiotic group) basal diet + Lactobacillus acidophilus @ 0.5 gm (2 x 10 10 cfu/ g) + 2 g MOS per calf/day respectively for a period of 90 days. Significant weight gain was observed in probiotic and synbiotic group. The results showed that there was a significant increase in leucocyte count in T 1, T 2, and T 3 on 90 th day of experiment. Haemoglobin content was significantly higher from 30 days till completion of experimental study in T 1 , T 2 and T 3 groups than control group. T 1, T 2 and T 3 supplemented groups showed significantly higher values of Packed Cell Volume on 60 th and 90 th days as compared to control group. Significantly higher values of Mean corpuscular haemoglobin concentration were observed in T 1 , T 2 and T 3 group at 30 th day than control group. The treatment groups T 2 and T 3 showed significant increase in lymphocyte count on 90 th day than control group (T 0 ). Neutrophil count showed no significant difference except at 90 th day where T 1 , T 2 and T 3 showed significant difference from control group. It may therefore be concluded that supplementation of probiotic, prebiotic and synbiotic is advantageous in improving leucocyte count, haemoglobin content, and packed cell volume in crossbred calves.