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Here we introduce ccSOL omics, a webserver for largescale calculations of protein solubility. Our method allows (i) proteome-wide predictions; (ii) identification of soluble fragments within each sequences; (iii) exhaustive single-point mutation analysis. Results: Using coil/disorder, hydrophobicity, hydrophilicity, -sheet and -helix propensities, we built a predictor of protein solubility. Our approach shows an accuracy of 79% on the training set (36 990 Target Track entries). Validation ondoi:10.1093/bioinformatics/btu420 pmid:24990610 pmcid:PMC4184263 fatcat:yxsvnphkdvadpgix5w5p3la5me