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cAMP Sensitivity of HCN Pacemaker Channels Determines Basal Heart Rate But Is Not Critical for Autonomic Rate Control
Circulation: Arrhythmia and Electrophysiology
Background-HCN channels activate the pacemaker current I f , which is thought to contribute significantly to generation and regulation of heart rhythm. HCN4 represents the dominant isotype in the sinoatrial node and binding of cAMP was suggested to be necessary for autonomic heart rate regulation. Methods and Results-In a candidate gene approach, a heterozygous insertion of 13 nucleotides in exon 6 of the HCN4 gene leading to a truncated cyclic nucleotide-binding domain was identified in adoi:10.1161/circep.110.949768 pmid:20693575 fatcat:y3hcj6zcobeotjwmhfzxsh5wdy