To study levels of serum lactate dehydrogenase and serum uric acid in patients suffering from Leukemias

Dr Kriti Sharma, Dr. Vijay Mehra, Dr. Surinder Paul, Dr. Pashaura Singh, Dr. Permeet Kaur Bagga, Dr. Damini Sharma
2020 International Journal of Clinical and Diagnostic Pathology  
In India, Leukemia continues to be the largest contributor to cancer related mortality in children. Once the diagnosis of leukemia is suspected, a rapid evaluation and initiation of appropriate treatment is necessary. In addition biochemical test such as serum lactate dehydrogenase (LDH) activity and uric acid concentration have side by side gained importance in monitoring the prognosis of leukemia, especially during the phase of treatment. AIM: To evaluate serum lactate dehydrogenase and serum
more » ... uric acid levels in patients suffering from leukemias. Material and Methods: The study was based on fifty patients of leukemia-acute or chronic, lymphoid or myeloid, diagnosed as a case of leukemia, both male and female, irrespective of their age attending out-patient Department or admitted in various wards of Government Medical College and Hospital, Amritsar were taken and their serum LDH and serum uric acid levels were estimated. Informed consent of the patient was taken. All newly diagnosed leukemia cases irrespective of their age and sex with no previous history of taking any chemotherapeutic drugs were included in the study. Quantitative estimation of serum lactate dehydrogenase is estimated using LDH (P-L) kit with normal reference values Serum of 230-460 U/L at 37 °C and quantitative estimation of serum uric acid was carried out using in vitro diagnostic kit (IVD) and enzymatic calorimetric method (Trinder) in clinical chemistry analyzers. Results: Mean serum uric acid and Mean LDH activity in study population was found to be 7.69±1.02 mg/dl and 794.07±227.62 IU/L respectively. Maximum rise in serum uric acid concentration was observed in AML type while Maximum rise in serum uric acid concentration was observed in ALL type. Both mean serum LDH concentrations and mean serum uric acid concentrations with TLC Levels in leukemic patients, we observed a strong correlation between increased TLC levels. On correlation analysis association between it was observed that the relation between serum uric acid and serum LDH would be considered statistically significant. Conclusion: We can conclude that patients presenting with raised TLC along with hypercellular bone marrow and presenting with increased serum uric acid and LDH concentrations usually show poor prognosis in comparison to other leukemic patients.Thus continuous biochemical monitoring of serum LDH activity and uric acid concentration can play an important role in monitoring the prognostic aspect of the disease. Both serum uric acid and LDH measurement are easily available in laboratory and much cheaper parameters to assess disease progression. Keywords: serum lactate dehydrogenase, serum uric acid and Leukemias International Journal of Clinical and Diagnostic Pathology
doi:10.33545/pathol.2020.v3.i1d.181 fatcat:53glvvro3bcbhkdt2smnhinroi