Antiphospholipid syndrome (APS) is a rare autoimmune disease with an increased risk of vascular occlusion and pregnancy complications. As a multisystemic disease, the heart is usually affected by direct (autoimmune action) or indirect (thrombosis) pathological mechanisms. Case Report: A 40-year-old diabetic and hypertensive woman presented with congestive heart failure. The echocardiographic exploration showed reduced left ventricle ejection fraction (20%) and diffuse wall motion abnormalities

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... ith multiple large thrombi in the left ventricle. The coronary angiography was normal. The APS was confirmed by positive laboratory tests (La, aCL and aß2GPI). Conclusion: The revelation of APS by cardiac manifestations, mainly cardiac thrombosis, is rarely reported in the literature, and evolution is usually unfavorable..