Isolation of a new monoterpenoid glycoside from Anhua dark tea based on an NMR-guided method and its cytotoxic activity against MDA-MB-231 and SH-SY5Y cell lines

Yunqiang Zhang, Jianyu Liu, Miao Chen, Yanhua Fan, Meichen Li, Andong Wang, Gaigai Liu, Yongnan Xu, Xuhong Ren, Yan Xiao
2020 figshare.com  
Based on an NMR-guided method, one new monoterpenoid glycoside (1) was isolated from Anhua dark tea, together with five known compounds (2–6). The structure of the new compound was determined as 3-(5,5-dimethyltetrahydrofuranyl)-1-buten-3-ol primeveroside, and trivially named anhuaterpenoside A (1), on the basis of detailed spectroscopic analyses, and acidic hydrolysis. Compound 1 exhibits cytotoxic activity against MDA-MB-231 and SH-SY5Y cell lines with IC50 value of 23.26 μM and 18.57 μM, respectively.
doi:10.6084/m9.figshare.13186970.v1 fatcat:5pz65ckbzfhc5nqqdgq54hu4pu