We reported that hypotensive substances could be obtained from chlorella by alkali or hot water extraction and from young barley leaves by hot water extraction (presentation at the 3rd Int Symp on SHR; Jap Heart J: 20, Suppl: 1979 (in press)). We extended a search for hypotensive substances from various plants. Materials and Methods Seventy items of fifty five plants including fungi, used for daily foods, medicines, and garden plants, were examined. The samples of plants were homogenized using

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... mixer, homogenants were added to 10 volumes ble portion was fractionated on a column of Sephadex according to the previous report (above mentioned reference), and then freeze-dried. On the other hand the samples of fungi were suspended in 5 volumes of cold water, the mixtures were stirred for 3 days, and the water extracts were freeze-dried. Both freezedried substances were administered intravenously, intraperitoneally, subcutaneously, or intragastrically to SHRSP, SHR and normotensive Wistar-Kyoto rats. Blood pressure was measured chlonologically using the tail-pulse pickup method without anesthesia. Results Table 1 showed the results in intravenous injection of 5mg/100g body weight materials to SHRSP and SHR. Table 1. Effective Fractions from Various Plants and Their Molecular Weights *sweet, **astringent Summary We tried to obtain hypotensive substances in hot water or cold water extracts from seventy items of fifty five plants. Administered intravenously, fractions from mandarine orange leaves, lily bulbs, bamboo grass, spirulina, leek, bean sprout, chlorella, fomitopsis pinicola, mandarine orange peels, young barley leaves, persimmon leaves, and tomato plant leaves showed marked falls in blood pressure.