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Input-selective adenosine A1 receptor-mediated synaptic depression of excitatory transmission in dorsal striatum
AbstractThe medial (DMS) and lateral (DLS) dorsal striatum differentially drive goal-directed and habitual/compulsive behaviors, respectively, and are implicated in a variety of neuropsychiatric disorders. These subregions receive distinct inputs from cortical and thalamic regions which uniquely determine dorsal striatal activity and function. Adenosine A1 receptors (A1Rs) are prolific within striatum and regulate excitatory glutamate transmission. Thus, A1Rs may have regionally-specificdoi:10.1038/s41598-021-85513-x pmid:33737568 pmcid:PMC7973535 fatcat:bq2ylsr3ojb4vivyilijvoqqby