Effect of Dalbergia sissoo on lipid profile and oxidative stress in ovariectomized rats

Ambadas Mane, Sachin Tembhurne, Swati Kolhe
2018 Asian Journal of Pharmacy and Pharmacology  
Objective: In this study, we tested the effect of hydroalcoholic extract of on oxidative stress, lipid Dalbergia sissoo profile in 90 days postsurgical bilateral ovariectomized female rats. 3-month old female Material and Methods: Wistar rats were used and distributed in 6 groups: intact groups with 90 days, ovariectomized groups with 90 days, ovariectomized (Ovx) treated hydroalcoholic extract of (200, 350 and 500mg/kg p.o.), Dalbergia sissoo ovariectomized treated with standard β Estradiol
more » ... dard β Estradiol (0.1mg/kg/s.c). All the treatments were given for further 90 days after post-surgical period (90 days) in ovariectomized female rats. After 90 days of treatments serum estrogen level, level of thiobarbituric acid reactive substances and lipid profile were quantified. The treatment of the hydroalcoholic Results: extract of (200, 350 and 500mg/kg) in the Ovx rats shows significant increase in the serum estrogen Dalbergia sissoo level, normalization of lipid profile, decreased in the thiobarbituric acid reactive substances. All the results of Dalbergia sissoo are comparable with standard β Estradiol. Our results suggest that 90 days of treatment with Conclusion: hydroalcoholic extract of is able to increase the estrogen level thereby normalized the lipid profile and Dalbergia sissoo oxidative stress in ovariectomized rats.
doi:10.31024/ajpp.2018.4.6.11 fatcat:t3o54tinlrapzjrzvwomxjddca