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VE-PTP participates in vasculogenic mimicry by preventing autophagic degradation of VE-cadherin
[article]
2019
bioRxiv
pre-print
Aberrant extra-vascular expression of VE-cadherin has been observed in metastasis associated with Vasculogenic Mimicry (VM); we have recently shown that in VM prone (VM+) tumor cells VE-cadherin is mainly in the form of pVE-cadherin in Y658 allowing an increased plasticity that potentiates VM development. As excessive VE-cadherin phosphorylation is regulated by the phosphatase VEPTP in endothelial cells in the current study we analysed its role in this aberrant phenotype in malignant tumor
doi:10.1101/634584
fatcat:umfahllvajet7jkknc7zzh4uwy