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Effects of Simvastatin on the Expression of Heme Oxygenase-1 in Human RPE Cells
2012
Investigative Ophthalmology and Visual Science
PURPOSE. Chronic oxidative stress can lead to the impairment of RPE cells, indicating it to be a risk factor for AMD. The cholesterol-independent, pleiotropic effects of statins have protective effects on several cell types via unknown mechanisms. This study examined the role of heme oxygenase-1 (HO-1) as a target and potential mediator of statins in cultured human RPE cells. METHODS. The RPE cell viability was measured using a 3-(4,5dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay.
doi:10.1167/iovs.12-9658
pmid:22918643
fatcat:2jc7y55kwvgi3k553camupqzuy