Clean 3,4-Dihydropyrimidones Synthesis via Biginelli Reaction over Supported Molybdenum: Structural and Textural Characteristic of αMoO3

Ouzna Kheffache, Cristina Lopez-Olmos, Inmaculada Rodriguez-Ramos, Ouiza Cherifi
2020 Bulletin of Chemical Reaction Engineering & Catalysis  
A one-pot three-component synthesis of dihydropyrimidinones (DHPMs) via Biginelli reaction was carried out at 100 °C using benzaldehyde, ethyl acetoacetate and urea as reactants, in the presence of ethanol and free solvent, in heterogeneous catalytic medium. The Mo (30 wt%) metal oxides (Al2O3, SiO2 or MgO) used catalysts were prepared by sol-gel, impregnation and microemulsion methods and characterized by X-Ray Diffraction (XRD), Fourier Transform Infra Red (FTIR), Scanning Electron Microscopy
more » ... Electron Microscopy (SEM), Transmission Electron Microscopy (TEM), Energy Dispersive X-ray (EDX), Nitrogen Adsorption - Brunauer-Emmett-Teller (BET), and NH3-Temperature Programmed Desorption (TPD) methods. The Mo-SiO2 sample prepared by the sol-gel method exhibited the highest DHPM yield (87%), in free solvent with a reaction time of 30 min. The high efficiency, in the Biginelli reaction, of the Mo-SiO2 catalyst is due to its structural, textural and acid properties. Highly dispersed αMoO3 species of orthorhombic structure having a high contribution of strong acidic sites would be the active species in the Biginelli synthesis Copyright © 2020 BCREC Group. All rights reserved
doi:10.9767/bcrec.15.3.8264.698-713 fatcat:xofpmsxl7zc2biwyvckyh42uyq