Helicobacter pylori, CagA-Positive Strains, and Ischemic Stroke * Response

M. Gabrielli, P. Pola, A. Gasbarrini, P. U. Heuschmann, M. Gesslein, B. Craiovan, B. Neundoerfer, P. L. Kolominsky-Rabas
2002 Stroke  
Stroke welcomes Letters to the Editor and will publish them, if suitable, as space permits. They should not exceed 750 words (excluding references) and may be subject to editing or abridgment. Please submit letters in duplicate, typed double-spaced. Include a fax number for the corresponding author and a completed copyright transfer agreement form (published in the January and July issues). . Association between plasma homocysteine concentrations and extracranial carotidartery stenosis. N Engl
more » ... Med. 1995;332:286 -291. 7. Eikelboom JW, Hankey GJ, Anand SS, Lofthouse E, Staples N, Baker RI. Association between high homocyst(e)ine and ischemic stroke due to large-and small-artery disease but not other etiologic subtypes of ischemic stroke. Stroke. 2000;31:1069 -75. 8. Jacques PF, Selhub J, Bostom AG, Wilson PWF, Rosenberg IH. The effect of folic acid fortification on plasma folate and total homocysteine concentrations. N Engl J Med. 1999;340:1449 -1454. Response: We thank Dr Kelly et al for their letter that emphasizes major aspects concerning the design of our study as well as the role of some genetic predisposing factors. As acknowledged by Kelly et al, we interpret our data to support the concept that, rather than single genes, the combination of several genes, each causing a small effect per se, is important to lead to complex human phenotypes such as stroke. Nevertheless, our data emphasize that, similar to factors such as cigarette smoking, hypertension, diabetes, and hyperlipidemia, hyperhomocysteinemia is more common in cases than in controls and is important to help identify subjects with a history of early-onset ischemic stroke.
doi:10.1161/01.str.0000016298.42331.9d pmid:12052969 fatcat:4fd3djlslzcd7ibpeczadcxawy