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Purpose: To report a case of a post-term neonate with an isolated cystic hygroma upon birth. Methods: This is a retrospective case report followed by clinical observation, genetic testing, and surgical intervention. Results: A post-term neonate was found with an isolated left parapharyngeal cystic hygroma with no incidence of concurrent genetic syndromes upon karyotyping and underwent surgical removal. Discussion: Cystic hygromas are very commonly associated with genetic syndromes or maternaldoi:10.51362/neonatology.today/20201215124447 fatcat:p7sogvngg5du7atsyezxxhezyq