The plant Anamirta cocculus Wild is used in traditional and folk medicine for various diseases. Thus the study was aimed to carry out preliminary pharmacological screening for its cardiovascular effects. The effect of the extract on perfused blood vessels of frog and perfused frog heart was studied. The extract produced vasodilator effect and decrease cardiac output in perfused blood vessels of frog. The extract showed a depressant effect on perfused frog heart. The action was not blocked by

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... opine. It also blocked the action of adrenaline on heart. The results of the study indicated that the extract might have antiarrhythmic activity.