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Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy
2002
Human Molecular Genetics
Protein conformational disorders (PCDs), such as Alzheimer's disease, Huntington's disease (HD), Parkinson's disease and oculopharyngeal muscular dystrophy, are associated with proteins that misfold and aggregate. Here we have used exon 1 of the HD gene with expanded polyglutamine [poly(Q)] repeats and enhanced green fluorescent protein tagged to 19 alanines as models for aggregate-prone proteins, to investigate the pathways mediating their degradation. Autophagy is involved in the degradation
doi:10.1093/hmg/11.9.1107
pmid:11978769
fatcat:tu64gkxpanew3ozyultecrtrly