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Focal CA3 hippocampal subfield atrophy following LGI1 VGKC-complex antibody limbic encephalitis
2017
Brain
Magnetic resonance imaging has linked chronic voltage-gated potassium channel (VGKC) complex antibody-mediated limbic encephalitis with generalized hippocampal atrophy. However, autoantibodies bind to specific rodent hippocampal subfields. Here, human hippocampal subfield (subiculum, cornu ammonis 1-3, and dentate gyrus) targets of immunomodulation-treated LGI1 VGKC-complex antibody-mediated limbic encephalitis were investigated using in vivo ultra-high resolution (0.39 Â 0.39 Â 1.0 mm 3 ) 7.0
doi:10.1093/brain/awx070
pmid:28369215
pmcid:PMC5405234
fatcat:z2tjc7sw6jfftclblx4qrezdua