Correlation of urinary markers versus blood biomarkers in osteoporotic fractures

Ganesan Ganesan, Ram, P Vijayaraghavan
Indian Journal of Orthopaedics Surgery   unpublished
Little has been published on the biochemical changes that can cause or a predisposing factor for osteoporotic fracture. The aim of the study is to assess whether there is any correlation of fracture to the level of serum parathyroid hormone, serum vitamin D and urinary n telopeptide. Materials and Methods: Prospective study done at Sri Ramachandra Institute of Medical Science, Chennai between October 2015 to October 2017.The Inclusion criteria were persons above 50 years of age and the patients
more » ... above 50 who comes within 24 hrs following trivial fall fractures. All patients who participated in the study underwent Dexa scan for diagnosis of osteoporosis, urinary n telopeptide and biochemical tests like serum calcium, serum phosphate, Alkaline phosphatase, 25-hydroxy vitamin D and serum parathyroid. The patients were divided into two groups. Group I had patients without fracture and Group II had patients who had osteoporotic fractures. Results: We had nearly twenty one pertrochantric fractures patients followed by sixteen distal radius patients. The mean value of urinary n telopeptide was 55.7 in group I and 186.39 in group II. The mean value of serum PTH was 69.5 in group I and 72.9 in group II. Conclusion: Urinary marker correlates well with the osteoporotic fracture and will be a better diagnostic tool than the blood biomarkers of osteoporosis.