Biomarkers in Neurodegenerative Diseases: Proteomics Spotlight on ALS and Parkinson's Disease

Rekha Raghunathan, Kathleen Turajane, Li Chin Wong
2022 International Journal of Molecular Sciences  
Neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and Parkinson's disease (PD) are both characterized by pathogenic protein aggregates that correlate with the progressive degeneration of neurons and the loss of behavioral functions. Both diseases lack biomarkers for diagnosis and treatment efficacy. Proteomics is an unbiased quantitative tool capable of the high throughput quantitation of thousands of proteins from minimal sample volumes. We review recent proteomic studies
more » ... n human tissues, plasma, cerebrospinal fluid (CSF), and exosomes in ALS and PD that identify proteins with potential utility as biomarkers. Further, we review disease-related post-translational modifications in key proteins TDP43 in ALS and α-synuclein in PD studies, which may serve as biomarkers. We compare relative and absolute quantitative proteomic approaches in key biomarker studies in ALS and PD and discuss recent technological advancements which may identify suitable biomarkers for the early-diagnosis treatment efficacy of these diseases.
doi:10.3390/ijms23169299 pmid:36012563 pmcid:PMC9409485 fatcat:6qexgdt2pvdvvhbj3yj3h3eq34