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Transporters are key to understanding how an individual will respond a particular dose of a drug. Two patients with similar systemic concentrations may have quite different local concentrations of a drug at the required site. The transporter profile of any individual depends upon a variety of genetic and environmental factors, including genotype, age, and diet status. Robust models (virtual patients) are therefore required and these models are data hungry. Necessary data include quantitativedoi:10.1146/annurev-anchem-091719-024553 pmid:32084322 fatcat:xdczamqzcja4jg6gtdamebvdlq