Validation of the Williams ultrasound scoring system for the diagnosis of liver disease in cystic fibrosis

Eleonora D.T. Fagundes, Rogério A. P. Silva, Mariza Leitão Valadares Roquete, Francisco J. Penna, Francisco J.C. Reis, Eugênio M.A. Goulart, Cristiano G. Duque
2004 Jornal de Pediatria  
Objectives: To describe the hepatic abnormalities revealed by ultrasound examination of cystic fibrosis (CF) patients followed at the CF Outpatient Clinic at the Federal University of Minas Gerais; to compare ultrasound data with clinical and biochemical parameters; to validate the Williams ultrasound score for the diagnosis of liver disease in CF. Methods: Seventy cystic fibrosis patients were followed prospectively and underwent clinical, biochemical and ultrasound examinations. The
more » ... findings were compared to the results of the clinical and biochemical examinations. Clinical and biochemical criteria were used as the gold standard for the validation of the Williams ultrasound score. We calculated the sensitivity, specificity, and positive and negative predictive values for the Williams score. The patients were divided into two groups: normal (score = 3) or abnormal (score > 3) ultrasound examination.
doi:10.2223/1222 pmid:15505733 fatcat:qzhgx23o4rginc4lzdnwtzw7lq