A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2018; you can also visit the original URL.
The file type is
Structures of ArsA with ATP, AMP-PNP, or ADP⅐AlF 3 bound at the A2 nucleotide binding site were determined. Binding of different nucleotides modifies the coordination sphere of Mg 2؉ . In particular, the changes elicited by ADP⅐AlF 3 provide insights into the mechanism of ATP hydrolysis. In-line attack by water onto the ␥-phosphate of ATP would be followed first by formation of a trigonal intermediate and then by breaking of the scissile bond between the ␤and ␥-phosphates. Motions of amino aciddoi:10.1074/jbc.m103671200 pmid:11395509 fatcat:mvzgbw5k4zfztjy2oilr2i7ixe