Pathways to Recovery and Loss of Nephrons in Anti-Thy-1 Nephritis

W. Kriz
2003 Journal of the American Society of Nephrology  
The present histopathologic study of anti-Thy-1.1 models of mesangioproliferative glomerulonephritis in rats provides a structural analysis of damage development and of pathways to recovery and to nephron loss. As long as the disease remains confined to the endocapillary compartment, the damage may be resolved or recover with a mesangial scar. Irreversible lesions with loss of nephrons emerge from extracapillary processes with crucial involvement of podocytes, leading to tuft adhesions to
more » ... adhesions to Bowman's capsule (BC) and suba Random sections always greatly underestimate the actual frequencies; note the large differences between the number of podocyte prolapses determined in serial and random sections (first two columns from left). n, number of glomeruli; n 1 , number of glomerular profiles.
doi:10.1097/01.asn.0000070073.79690.57 pmid:12819253 fatcat:7wmjue6d65dzrhvo63i72hs4fe