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Toxic Effects of Tramadol Abuse and Withdrawal on Histopathological Structure of Tongue in Sprague Dawley Rats
2021
Zagazig Journal of Forensic Medicine
Taste disturbance among tramadol abusers has been reported in the last few years. Aim: To assess the toxic effects of tramadol abuse on tongue structure including taste buds and reversibility of these changes on withdrawal. In addition, assess the effect of tramadol on Ki-67 as general marker for cellular proliferation. Methods: Forty-two adult male Sprague Dawley rats were divided into six groups: group I received normal saline, groups II and III received tramadol hydrochloride 40mg/kg for 20
doi:10.21608/zjfm.2021.88114.1087
fatcat:ivtm626fobdmndm2rmhm6g3dze