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Detection of time-dependent and oxidatively induced antigens of bovine liver rhodanese with monoclonal antibodies
Journal of Biological Chemistry
Rhodanese has been extensively utilized as a model protein for the study of enzyme structure-function relationships. An immunological study of conformational changes occurring in rhodanese as a result of oxidation or thermal inactivation was conducted. Three monoclonal antibodies (MABs) to rhodanese were produced. Each MAB recognized a unique epitope as demonstrated by binding of the MABs to different proteolytic fragments of rhodanese. While none of the MABs significantly bound native,pmid:2461938 fatcat:ksgt63ksxza6doo2tnkuhpxfgu