Mechanism and Physiological Significance of Growth Factor-Related Autophagy

Terytty Yang Li, Shu-Yong Lin, Sheng-Cai Lin
2013 Physiology  
Growth factors, typically defined as natural substances capable of stimulating cell growth and differentiation, are vital regulators for the survival of metazoan cells. In this review, we will focus on growth factor signaling pathways that are closely related to autophagy induction and discuss the critical roles of this fascinating cellular process in intracellular energy homeostasis, cell fate determination, and pathophysiological regulation. MH. Insulin antagonizes ischemia-induced Thr172
more » ... phorylation of AMP-activated protein kinase alpha-subunits in heart via hierarchical phosphorylation of Ser485/491.
doi:10.1152/physiol.00023.2013 pmid:24186937 fatcat:c3wijam6lrd63fthasrydmieru