Smoking has been associated with increased prevalence of cardiac and pulmonary diseases besidemalignancies and quitting smoking is the best way to prevent development of smoking related diseases. Behavioural support and pharmacotherapy help people quit smoking. Medications are recommended for smokers with nicotine dependance. Varenicline is one of the effective and safe pharmacological monotherapy for the treatment of tobacco dependence. Compared with other medications abstinance rates of

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... ts is higher for varenicline. Although concerns about neuropsychiatric safety of varenicline arose previously from case reports, post-marketing surveillance, recent studies demonstrated that that use of varenicline did not increase neuropsychiatric symptom risk. The drug also can be used in stabil cardiovascular diseases since current evidence does not show an increased risk.