Electrochemical Determination of Serotonin and the Competitive Adsorption with Dopamine at 5,5-Ditetradecyl-2-(2-trimethylammonioethyl)-1,3-dioxane Bromide Lipid Film Modified by Glassy Carbon Electrode

Jing-Ming GONG, Xiang-Qin LIN
2004 Analytical Sciences  
A novel and effective approach to sensitively determine serotonin, known as 5-hydroxytryptamine (5-HT), has been proposed based on a 5,5-ditetradecyl-2-(2-trimethylammonioethyl)-1,3-dioxane bromide (DTDB) self-assembled lipid bilayer membrane modified glassy carbon electrode (DTDB/GCE). A DTDB/GCE shows the strong electrocatalysis for the oxidation of 5-HT, with the peak potential shifted to less positive value of 0.376 V vs. SCE, and effectively eliminates the interference from ascorbic acid
more » ... rom ascorbic acid (AA), even in the presence of 100-fold concentration of AA. Differential pulse voltammetry (DPV) gave a linear current for 5-HT from 2.0 × 10 -7 to 1.0 × 10 -5 M. At the DTDB/GCE, the oxidation of 5-HT was controlled by the adsorption process; for 5-HT coexisting with DA, the competitive adsorption was observed.
doi:10.2116/analsci.20.905 pmid:15228108 fatcat:fc37lmzkdzhb7mpaexqe55q3si