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JASPAR (http://jaspar.genereg.net) is an openaccess database storing curated, non-redundant transcription factor (TF) binding profiles represent- ing transcription factor binding preferences as position frequency matrices for multiple species in six taxonomic groups. For this 2016 release, we expanded the JASPAR CORE collection with 494 new TF binding profiles (315 in vertebrates, 11 in nematodes, 3 in insects, 1 in fungi and 164 in plants) and updated 59 profiles (58 in vertebrates and 1 indoi:10.1093/nar/gkv1176 pmid:26531826 pmcid:PMC4702842 fatcat:dfyf2xpuprh4pg2udndeovgxrm