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Origin of the hemoglobin S gene in a northern Brazilian population: the combined effects of slave trade and internal migrations
1998
Genetics and Molecular Biology
We analyzed DNA polymorphisms in the <FONT FACE="Symbol">b</font>-globin gene cluster of 30 sickle cell anemia patients from Belém, the capital city of the State of Pará, in order to investigate the origin of the <FONT FACE="Symbol">b</font>S mutation. Sixty-seven percent of the <FONT FACE="Symbol">b</font>S chromosomes were Bantu type, 30% were Benin type, and 3% were Senegal type. The origin of the <FONT FACE="Symbol">b</font>S mutation in this population, estimated on the basis of <FONT
doi:10.1590/s1415-47571998000400001
fatcat:xapazeaz4feedg4iv5voeyjiza