Parallels of structural-functional parameters the myocardium, C-type natriuretic peptide and endothelin-1 plasma concentrations in women with uncomplicated essential hypertension

V. V. Petrovska, B. M. Zhebel
2014 Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki  
The development of endothelial dysfunction (DE)plays an important role in the pathogenesis of essential hypertension (EH). Processes of vascular wall remodeling (hyperplasia and hypertrophy of smooth muscle cells of the media, fibrosis) cause progression and stabilization of arterial hypertension [7] and lead to the development of cardiac dysfunction with its subsequent remodeling. From this point of view the study of plasma concentrations of vasodilator-natriuretic peptide C and its direct
more » ... gonist endothelin-1 is an important task. Objective: to study plasma concentrations of SNP and ET-1 at changes in state infarction in women ofpostmenopausal age, residents of Vinnytsia region suffering from uncomplicated essential hypertension. Materials and methods. 101 Womenhave been examined, patients with essential hypertension, aged from 45 to 65, all are residents of Vinnytsia region. 51 Patients have GC stage I and other 50 stage II -HH. The control group was formed by 80 women without any cardio - vascular diseases. The selection of subjects was carried out on the basis of detailed history taking and examination using standard clinical, laboratory and instrumental methods of examination. We useddaily monitoring of blood pressure, heart ultrasound, ELISA. Land Survey SNP level, ET-1 and SNP / ET-1 has been determined according to the methodology MU Antamonova. The data has been processed using a standard statistical package Statistica 6,0. Results. According to received information plasma concentrations of SNP and ET-1 in female patients with EH of postmenopausal age were significantly higher than in healthy women of this age, while in patients with essential hypertension stage II plasma levels in their blood were significantly higher than the GC and stage (p <0.01). That level of SNP and ET-1 are associated with the severity of GC. To assess the balance of activity of vasodilators, vasoconstrictors in plasma can be used in ratio SDA / ET-1 (utility model №72156). It has been established that at any stage of GC v [...]
doi:10.14739/2409-2932.2014.3.33895 doaj:e94ef10532f84ca4b541b69aad9850b9 fatcat:rpchyhzqczhktn57wp6t7d23eq