Heparan Sulfate Proteoglycans during Terminal Skeletal Muscle Cell Differentiation: Possible Functions and Regulation of their Expression

Enrique Brandan, Juan Larrain
1998 Basic Appl Myol   unpublished
Heparan sulfate proteoglycans are key molecules found associated with the cell surface and extracellular matrix (ECM). These macromolecules seem to be essential to achieve terminal skeletal muscle differentiation. In this review, we present data about the types of beparan suifate proteoglycans present in skeletal muscle cells, how their expression changes during differentiation and we propose some mechanisms that might be controlling and/or affecting their expression. Finally, we discuss some
more » ... ssible Functions for these heparan sulfate proteoglycans during skeletal muscle differentiation.