Halophilic actinomycetes isolated from the saltpan soil samples of sambai saltpan,ramanathaburam,tamilnadu,india.SHA-1 strains are shows the best antagonistic and antibacterial activity against the Gram Positive-Stapylocoocus aureus, Stapylocoocus saprophyticus, Streptococcus pneumoniae, Enterococus faecalis, Enterobacter aerogens and Gram negative-Escherichia coli ,Salmonella typhi, Klebsiella pneumoniae ,pseudomonas aeruginosa and serratia marcescens. The potential strains were confirmed

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... level as Streptomyces sp by morphological, physiological and biochemical identification. Morphological identification was done by gram staining shows filamentous branch structure and SEM analysis shows the 2µm in size. The exploration of new antibiotics are isolated from unexploted saline environments.