Issue:2 Citation

Rohit Bhor, Rahul Kunkulol
2016 Human Journals Research Article April   unpublished
Chromones and Pyrazole derivatives were reported wide range of biological activities. Hence, it was planned to synthesize and screen for their antibacterial (in vitro) activity. A series of novel 2-acetyl-4-chlorophenyl pentafluorobenzoate derivatives were synthesized and evaluated for in-vitro antibacterial activity. Chromones and Pyrazole derivatives like 6-chloro-2-(pentafluorophenyl)-4H-chromen-4-one, 4-chloro-2-[5-(pentafluorophenyl)-1H-pyrazol-3-yl]phenol were synthesized by a sequence of
more » ... ed by a sequence of reactions starting 2-acetyl-4-chlorophenyl pentafluorobenzoate and were mentioned in scheme 1. Antibacterial activities of chromones derivatives, Pyrazole derivatives were tested by the disc diffusion method by using Mueller Hinton Agar (M173) medium against various microorganisms such as Gram-positive Staphylococcus aureus, Gram-negative Escherichia coli and Pseudomonas aeruginosa. Gentamycin at 100μg/ml was used as standard drugs for antibacterial. Characterization of all the compounds were performed by IR, 1H NMR and Mass spectroscopy. The anti-inflammatory data suggested that compounds BC, BD and BE showed significant activity. The compounds bearing nitro and oxygen groups have shown prominent activity when compared to compounds without these groups.