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ABO phenotype protected reproduction as it is based on fucosylations
The molecular biological relationship between human fertility and ABO(H) blood group phenotype formation becomes evident with the rare (Oh) or Bombay blood type, which, based on the history of his own family, Charles Darwin would have interpreted as resulting from reduced fertility in consanguinities. In its native form, the Bombay type occurs in individuals with an extremely rare genotype (h/h;se/se), by which the fucosyltransferases FUT1 and FUT2 are not produced due to point mutations. Thesedoi:10.6084/m9.figshare.1409398.v267 fatcat:t4iz5pywojcczbkycch75dqqzi