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Objectives To identify core challenges and first steps on the way to sustainable information systems in healthcare. Methods Recent articles on healthcare information technology and related articles from Medical Informatics and Computer Science were reviewed and analyzed. Core challenges that couldn't be solved over the years are identified. Results The two core problem areas are process integration, meaning to effectively embed IT-systems into routine workflows, and systems integration, meaningdoi:10.1055/s-0038-1638640 fatcat:lmzspms42vce3gp5w3nzednttm