Analgesic Effects of ChondroT in Collagenase-induced Osteoarthritis Rat Model
Collagenase로 유발된 동물모델에서 ChondroT의 진통효과에 관한 연구

Jeong-Yoon Won, Ji-Won Jeong, Chang-Su Na, Seon-Jong Kim
2016 Journal of Korean Medicine Rehabilitation  
Objectives The purpose of this study was to find out the effects of ChondroT on arthralgia of the Collagenase-induced osteoarthritis in rats. Methods Osteoarthritis was induced into rat by injecting Collagenase in its knee joint. Rats are divided into a total of 8 groups (n=6). Normal group was not induced for osteoarthritis whereas control groups were induced for osteoarthritis by Collagenase. Positive-A (Indomethacin) was injected with Collagenase and after 8 days, 2 mg/kg of Indomethacin was
more » ... medicated. Positive-B (JOINS TAB) was injected with Collagenase and after 8 days, 20 mg/kg of JOINS TAB was medicated. Experimental groups (Chondro T) at three dose levels (50, 100 and 200 mg/kg) were injected with Collagenase and after 8days they were medicated with 10 ml/kg. Indomethacin, JOINS TAB and ChondroT were medicated each substances once a day for 10 days. Thereafter, the changes in plantar withdrawal response of osteoarthritis rats by dynamic plantar aesthesiometer were observed and then RT-PCR analysis was done to investigate the expression of related proteins.
doi:10.18325/jkmr.2016.26.3.17 fatcat:qdfncsnp5ngpjbsi35xebdmwaq