Vitamin D Deficiency and Associated Factors in Patients with Mental Disorders Treated in Routine Practice

Svetlana RISTIC, Sandra ZIVANOVIC, Dragan R. MILOVANOVIC, Vladimir JANJIC, Danijela DJOKOVIC, Ana JOVICEVIC, Marijana Stanojevic PIRKOVIC, Sanja KOCIC
2017 Journal of Nutritional Science and Vitaminology  
This research aimed to investigate factors associated with vitamin D deficiency and to provide data about its prevalence in patients suffering from different psychiatric illnesses. The study had a cross-sectional design and it included 220 patients of both genders, aged from 19-81 y, with a wide range of mental disorders (F00-F89), and treated in routine ambulatory and hospital practice. The researchers collected data from three sources: medical records, a study questionnaire and biochemical
more » ... lysis of patients' serum samples (concentration of vitamin D measured as 25(OH)D, calcium, phosphorus, magnesium, sodium and potassium). Data were analyzed using descriptive statistics, methods for hypothesis testing and binary logistic regression, at the p#0.05 level. A total of 140 patients (64%) had a deficiency of vitamin D (,12 ng/mL), and 45 (20%) had inadequate vitamin D serum levels (12-20 ng/mL), while 35 (16%) had sufficient vitamin D serum concentrations (.20 ng/mL). Among variables related to demographics, life style habits, mental illness, comorbid disorders and drugs, two of them, female gender (odds ratio (OR)52.5, 95% confidence interval (CI)51.3-4.9, p50.006) and using clozapine (OR515.6, 95% CI 1.7-144.7, p50.02), were significantly associated with vitamin D deficiency. Physical activity (OR5 0.4, 95% CI 0.2-0.9, p50.02), exercising (OR50.2, 95% CI ,0.1-0.7, p50.02) and offal in the diet (OR50.5, 95% CI 0.3-0.9, p50.03) significantly aggregated in the patients who had a 25(OH)D serum concentration above the deficiency cut-off level. Patients with mental disorders are at high risk for vitamin D deficiency, particularly females and clozapine users as well as those having no adequate physical activity or dietary habits.
doi:10.3177/jnsv.63.85 pmid:28552881 fatcat:my6pc6s7kbf6pgquyecgry4sde