Photothermal/microwave radiometry for imaging and temperature feedback

Vladimir P. Zharov, Sergey G. Vesnin, James Y. Suen, Steven E. Harms, Alexander A. Oraevsky
2002 Biomedical Optoacoustics III  
The goal of this work is to analyze the capabilities of a new photothermal (PT) radiometry system to control temperature during laser thermal therapy. The main feature of this system is the combination of two spectral channels: infrared (IR) and microwave (MW) ranges. The first channel provides information about the temperature distribution around the surface and subsurface of absorbing structures. The second channel provides information about the localized laser-induced thermal effects
more » ... mal effects occurring much more deeply, up to 3-5 cm. Experimental in vitro data obtained with a near-IR diode laser are presented, focusing on the estimated capabilities of the new MW radiometry as a system for providing feedback control for interstitial laser therapy. Further modifications of this system are suggested for PT radiometric confocal microscopy. The modifications are based on the combination of PT radiometry in time-resolved and frequency-domain modes, with confocal microscopy using reflected scanning modes. The potential advantages of these new approaches are discussed, including the imaging of tissue chromophores with high spatial resolution based on radiometric measurements of laser-induced thermal gradients.
doi:10.1117/12.469864 fatcat:huxq4qwnlbgytltdaxpovronzm