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Erythropoietin receptor regulates tumor mitochondrial biogenesis through iNOS and pAKT
Erythropoietin receptor (EPOR) is widely expressed in healthy and malignant tissues. In certain malignancies, EPOR stimulates tumor growth. In healthy tissues, EPOR controls processes other than erythropoiesis, including mitochondrial metabolism. We hypothesized that EPOR also controls the mitochondrial metabolism in cancer cells. To test this hypothesis, we generated EPOR-knockdown cancer cells to grow tumor xenografts in mice and analyzed tumor cellular respiration via high-resolutiondoi:10.5167/uzh-222276 fatcat:q6zeboznurawvkuiplz2ykvwxu