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Molecular motors are thought to generate force and directional motion via nonequilibrium switching between energy surfaces. Because all enzymes can undergo such switching, we hypothesized that the ability to generate rotary motion and torque is not unique to highly adapted biological motor proteins, but is instead a common feature of enzymes. We used molecular dynamics simulations to compute energy surfaces for hundreds of torsions in three enzymes, adenosine kinase, protein kinase A, and HIV-1doi:10.1101/121848 fatcat:kd27dkmwnncbfjw6qrkyncakla