Chronic obstructive pulmonary disease (COPD) is a chronic respiratory disease with the highest prevalence at present. It is mainly characterized by airflow limitation, high morbidity, lingering illness, recurrent attacks, high mortality, inflammatory reaction, heavy social and economic burden, and severe threat to patientsí quality of life. Pulmonary function rehabilitation training and atorvastatin can improve the pulmonary function of COPD patients, improve exercise endurance and

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... ry function (1-2). Aerobic exercise is a common pulmonary rehabilitation training method, but studies have shown that skeletal muscle atrophy will occur in patients with COPD, which is also one of the important factors for the decline of patientsí quality of life (3). Resistance in routine aerobic training can increase muscle strength, so aerobic resistance to training has a particular significance for the treatment of COPD. Bronchodilators and glucocorticoids are often used in the clinical treatment of COPD. Recent studies have shown that atorvastatin, a commonly used lipid-regulating drug in clinical practice, has anti-inflammatory, antioxidant, and immunomodulatory effects, and can reduce the mortality and hospitalization risk of COPD patients (4-5). However, there are few studies on the treatment of COPD by atorvastatin. The purpose of this study was to investigate the therapeutic efficacy of aerobic resistance exercise combined with atorvastatin in the treatment of COPD and to provide a basis for the treatment of COPD. EXPERIMENTAL Materials Patients 147 patients with COPD hospitalized in the internal medicine department of our hospital from DRUG BIOCHEMISTRY Abstract: Chronic obstructive pulmonary disease (COPD) is a chronic respiratory disease seriously threatening the quality of life of patients. In the treatment of patients with COPD at a stable stage, aerobic resistance exercise is not only needed to help patients recover their exercise function but also medication is needed to inhibit the production of inflammatory factors. This study discussed the feasibility of combining aerobic resistance exercise with medication to treat COPD. One hundred forty-seven patients with COPD who were hospitalized in the internal medicine department of our hospital from October 2015 to June 2019 were selected, and 120 patients were selected as subjects of this experiment on a voluntary basis. Aerobic resistance exercise therapy, atorvastatin, and combination therapy were performed respectively, and the patientsí physical fitness indicators, levels of inflammatory cytokines, and cardiopulmonary function were observed to evaluate treatment plans. After receiving the treatment of aerobic and obstructive exercise combined with atorvastatin, COPD patients showed improvement in the indicators related to physical fitness, including decreased body fat percentage, waist-to-hip ratio, BMI, blood sugar, hba1c content, and blood lipid, decreased levels of inflammatory factors like IL-8, IL-6, TNF-α, and some recovery in cardiopulmonary function. A combination of aerobic and obstructive exercise with atorvastatin can better treat COPD and improve the exercise function and cardiopulmonary function of patients. However, the clinical application of this treatment plan needs more cases to verify, and clinical application also needs to adjust the plan appropriately according to individual differences.