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Genetic architecture and evolution of color variation in American black bears

Emily E Puckett, Isis S Davis, Dawn C Harper, Kazumasa Wakamatsu, Gopal Battu, Jerrold L Belant, Dean E Beyer, Colin Carpenter, Anthony P Crupi, Maria Davidson, Christopher S DePerno, Nicholas Forman (+30 others)
2022

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Color variation is a frequent evolutionary substrate for camouflage in small mammals, but the underlying genetics and evolutionary forces that drive color variation in natural populations of large mammals are mostly unexplained. The American black bear, Ursus americanus (U. americanus), exhibits a range of colors including the cinnamon morph, which has a similar color to the brown bear, U. arctos, and is found at high frequency in the American southwest. Reflectance and chemical melanin
more » ... ents showed little distinction between U. arctos and cinnamon U. americanus individuals. We used a genome-wide association for hair color as a quantitative trait in 151 U. americanus individuals and identified a single major locus (p < 10-13). Additional genomic and functional studies identified a missense alteration (R153C) in Tyrosinase-related protein 1 (TYRP1) that likely affects binding of the zinc cofactor, impairs protein localization, and results in decreased pigment production. Population genetic analyses and demographic modeling indicated that the R153C variant arose 9.36 kya in a southwestern population where it likely provided a selective advantage, spreading both northwards and eastwards by gene flow. A different TYRP1 allele, R114C, contributes to the characteristic brown color of U. arctos but is not fixed across the range.
doi:10.1016/j.cub.2022.11.042 pmid:36528024 pmcid:PMC10039708 fatcat:gjvbfubytragxmzinp2miqswhi
Citation

Emily E Puckett, Isis S Davis, Dawn C Harper, Kazumasa Wakamatsu, Gopal Battu, Jerrold L Belant, Dean E Beyer, Colin Carpenter, Anthony P Crupi, Maria Davidson, Christopher S DePerno, Nicholas Forman, Nicholas L Fowler, David L Garshelis, Nicholas Gould, Kerry Gunther, Mark Haroldson, Shosuke Ito, David Kocka, Carl Lackey, Ryan Leahy, Caitlin Lee-Roney, Tania Lewis, Ashley Lutto, Kelly McGowan, Colleen Olfenbuttel, Mike Orlando, Alexander Platt, Matthew D Pollard, Megan Ramaker, Heather Reich, Jaime L Sajecki, Stephanie K Sell, Jennifer Strules, Seth Thompson, Frank van Manen, Craig Whitman, Ryan Williamson, Frederic Winslow, Christopher B Kaelin, Michael S Marks, Gregory S Barsh. "Genetic architecture and evolution of color variation in American black bears." (2022) 86-97.e10