Heparin like Syndrome is an entity discovered in 1980s. Although uncommon in clinical practice, this syndrome can lead to death in many cases because of severe bleeding. We report the fourth clinical case of a heparin like Syndrome associated to multiple Myeloma and acute kidney injury with a favourable outcome. We describe the evolution of clinical bleeding as activated partial thromboplastin time (APTT) and CD138 (transmembrane heparin sulphate on tumor cells surface) dosage over time.