A liver fibrosis is the basic element in the development of pathological processes in the liver tissue, and fibrosis degree is a specific sensitive enough marker in case of pathological changes in the liver under the influence of different etiologic factors. There are invasive, minimally invasive and non-invasive methods for detecting liver fibrosis. Invasive methods includes needle biopsy as a gold standard. Direct and indirect fibrosis markers belong to minimally invasive techniques.

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... ive methods include elastography and elastometry. Modern hepato­logy used all of these methods.