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Human Brain Mapping
The neural substrate underlying cognitive impairments after chemotherapy is largely unknown. Here, we investigated very late (>9 years) effects of adjuvant high-dose chemotherapy on brain white and gray matter in primary breast cancer survivors (n ¼ 17) with multimodal magnetic resonance imaging (MRI). A group of breast cancer survivors who did not receive chemotherapy was scanned for comparison (n ¼ 15). Neuropsychological tests demonstrated cognitive impairments in the chemotherapy group.doi:10.1002/hbm.21422 pmid:22095746 fatcat:r23r7kfhd5akzdds6d3jyk7pkq