Analysis of Morphogenic Effect of hDAB21P on Prostate Cancer and Its Disease Correlation [report]

Jer-Tsong Hsieh
2008 unpublished
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more » ... torate for Information Operations and Reports (0704-0188), 1215 Jefferson Davis Highway, Suite 1204, Arlington, VA 22202-4302. Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to any penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. for prostate cancer. We have established that calcitriol (1,25-dihydroxyvitamin D3) directly stimulates MIS expression by binding to the vitamin D receptor (VDR) and directing the hormone-receptor complex to bind to a vitamin D regulatory element (VDRE) in the MIS promoter. We have attempted to demonstrate that combination of calcitriol and MIS achieve increased potency to inhibit prostate cancer cell growth compared to either drug alone. However, this has not yet been accomplished. We further demonstrated the interaction of calcitriol-VDR with other transcription factors, SF-1, SOX-9and GATA-4, to act together to synergistically increase MIS expression in prostate cancer cells. We believe that some of calcitriol's action to inhibit prostate cancer cell growth is due to stimulation of MIS and this work plans to substantiate this hypothesis and lay the ground work to translate this information to clinical trials in men with prostate cancer. SUBJECT TERMS No subject terms provided. SECURITY CLASSIFICATION OF: 17. LIMITATION OF ABSTRACT 18. NUMBER OF PAGES 19a. NAME OF RESPONSIBLE PERSON USAMRMC a. REPORT U b. ABSTRACT U c. THIS PAGE U UU 33 19b. TELEPHONE NUMBER (include area code) Standard Form 298 (Rev. 8-98)
doi:10.21236/ada482660 fatcat:rmq6zp7vgraxfbujh7yetcrv5q