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Conjugation of cRGD Peptide to ChlorophyllaBased Photosensitizer (HPPH) Alters Its Pharmacokinetics with Enhanced Tumor-Imaging and Photosensitizing (PDT) Efficacy
2011
Molecular Pharmaceutics
The R v β 3 integrin receptor plays an important role in human metastasis and tumor-induced angiogenesis. Cyclic Arg-Gly-Asp (cRGD) peptide represents a selective R v β 3 integrin ligand that has been extensively used for research, therapy, and diagnosis of neoangiogenesis. For developing photosensitizers with enhanced PDT efficacy, we here report the synthesis of a series of bifunctional agents in which the 3-(1 0 -hexyloxyethyl)-3-devinylpyropheophorbide a (HPPH), a chlorophyll-based
doi:10.1021/mp200018y
pmid:21702452
pmcid:PMC3148296
fatcat:hadale77qbfkzluvda446j2t4y