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17β-estradiol suppresses hyperoxia-induced apoptosis of oligodendrocytes through paired-immunoglobulin-like receptor B
Molecular Medicine Reports
Hyperoxia is a high risk factor for neurodevelopmental disorders and can cause nerve cell death. 17β-Estradiol (E2) has been demonstrated as a neuroprotective agent. In the present study, the effect of hyperoxia on rat oligodendrocyte precursor cells (OPCs) in vivo and the neuroprotective effects of E2 on these cells were investigated. OPCs were treated with various concentrations of E2 and were harvested for reverse transcription-quantitiative polymerase chain reaction (RT-qPCR) analysis atdoi:10.3892/mmr.2016.4808 pmid:26821234 fatcat:6ql4stzy6zfqbdm5nxser3diyy